Macro‐creatine kinase: a neglected cause of elevated creatine kinase
Identifieur interne : 000158 ( France/Analysis ); précédent : 000157; suivant : 000159Macro‐creatine kinase: a neglected cause of elevated creatine kinase
Auteurs : F. Aljuani [France] ; A. Tournadre [France] ; S. Cecchetti [France] ; M. Soubrier [France] ; J. J. Dubost [France]Source :
- Internal Medicine Journal [ 1444-0903 ] ; 2015-04.
Abstract
Macro‐creatine kinase (macro‐CK) is a neglected cause of raised CK. Over a 10‐year period, we observed five cases. Three patients had macro‐CK type 1. One patient with fibromyalgia underwent several explorations to find a muscular pathology; another, who had elevated CK‐MB (muscle–brain fraction) activity, was referred to a cardiologist, and statin therapy was erroneously discontinued in two patients. Two patients had macro‐CK type 2: a man with a neuroendocrine carcinoma and a woman with rheumatoid arthritis. Diagnosis of type 1 obviates the need to carry out pointless and expensive investigations seeking a neuromuscular or cardiac pathology, and also, the unwarranted discontinuation of statin therapy. Type 2 must prompt investigations for a neoplasm.
Url:
DOI: 10.1111/imj.12710
Affiliations:
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Dubost</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, G. Montpied Hospital, Clermont‐Ferrand University, Clermont‐Ferrand</wicri:regionArea><wicri:noRegion>Clermont‐Ferrand</wicri:noRegion><wicri:noRegion>Clermont‐Ferrand</wicri:noRegion></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">France</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Internal Medicine Journal</title><title level="j" type="alt">INTERNAL MEDICINE JOURNAL</title><idno type="ISSN">1444-0903</idno><idno type="eISSN">1445-5994</idno><imprint><biblScope unit="vol">45</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="457">457</biblScope><biblScope unit="page" to="459">459</biblScope><biblScope unit="page-count">3</biblScope><date type="published" when="2015-04">2015-04</date></imprint><idno type="ISSN">1444-0903</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1444-0903</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Macro‐creatine kinase (macro‐CK) is a neglected cause of raised CK. Over a 10‐year period, we observed five cases. Three patients had macro‐CK type 1. One patient with fibromyalgia underwent several explorations to find a muscular pathology; another, who had elevated CK‐MB (muscle–brain fraction) activity, was referred to a cardiologist, and statin therapy was erroneously discontinued in two patients. Two patients had macro‐CK type 2: a man with a neuroendocrine carcinoma and a woman with rheumatoid arthritis. Diagnosis of type 1 obviates the need to carry out pointless and expensive investigations seeking a neuromuscular or cardiac pathology, and also, the unwarranted discontinuation of statin therapy. Type 2 must prompt investigations for a neoplasm.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Aljuani, F" sort="Aljuani, F" uniqKey="Aljuani F" first="F." last="Aljuani">F. Aljuani</name></noRegion><name sortKey="Cecchetti, S" sort="Cecchetti, S" uniqKey="Cecchetti S" first="S." last="Cecchetti">S. Cecchetti</name><name sortKey="Dubost, J J" sort="Dubost, J J" uniqKey="Dubost J" first="J. J." last="Dubost">J. J. Dubost</name><name sortKey="Dubost, J J" sort="Dubost, J J" uniqKey="Dubost J" first="J. J." last="Dubost">J. J. Dubost</name><name sortKey="Soubrier, M" sort="Soubrier, M" uniqKey="Soubrier M" first="M." last="Soubrier">M. Soubrier</name><name sortKey="Tournadre, A" sort="Tournadre, A" uniqKey="Tournadre A" first="A." last="Tournadre">A. Tournadre</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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